The Hang Seng Index fell 0.2 percent, to 25,615.
On the mainland, the Shanghai Composite Index lost 0.3 percent, to 2,893 and the Shenzhen Composite Index fell 0.1 percent, to 1,593.
Other Asian markets were volatile, gripped by uncertainty over the China-US trade talks with warnings that Donald Trump’s unpredictability could be harming the chances of an eventual agreement.
Tokyo ended 0.1 percent higher, Seoul was 0.9 percent up and Sydney rose 0.5 percent, with gains also in Taipei, Wellington, Manila and Jakarta.
But Singapore also shed 0.2 percent in the afternoon and Mumbai dropped 0.4 percent.
Stephen Innes at Valour Markets said: “There remains a high degree of scepticism regarding the sincerity of Trump’s comments or even if the Chinese are willing to recommence negotiations.”
He pointed out that an inflammatory tweet on Friday in which Trump labelled Federal Reserve boss Jerome Powell and President Xi Jinping enemies of the US had resonated among traders.
“Risk-off remains in vogue as trade disputes continue to flare, suggesting any risk assets recovery will remain extremely fragile,” he said.
Yuan edged up slightly after its latest sharp sell-off, but remains lodged around 11-year lows while oil prices climbed more than 1 percent to build on Tuesday’s surge. (AFP)